Reactive oxygen species initiate a metabolic collapse in hippocampal slices: potential trigger of cortical spreading depression

Excessive accumulation of reactive oxygen species (ROS) underlies oxidative damage. We find that in hippocampal slices, decreased activity of glucose-based antioxidant system induces a massive, abrupt, and detrimental change in cellular functions. We call this phenomenon metabolic collapse (MC). Thi...

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Detalhes bibliográficos
Main Authors: Malkov, Anton, Ivanov, Anton I, Popova, Irina, Mukhtarov, Marat, Gubkina, Olena, Waseem, Tatsiana, Bregestovski, Piotr, Zilberter, Yuri
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2014
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Original Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4158675/
https://ncbi.nlm.nih.gov/pubmed/25027308
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/jcbfm.2014.121
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