Ablation of MMP9 gene ameliorates paracellular permeability and fibrinogen–amyloid beta complex formation during hyperhomocysteinemia

Increased blood level of homocysteine (Hcy), called hyperhomocysteinemia (HHcy) accompanies many cognitive disorders including Alzheimer's disease. We hypothesized that HHcy-enhanced cerebrovascular permeability occurs via activation of matrix metalloproteinase-9 (MMP9) and leads to an increase...

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Detalhes bibliográficos
Main Authors: Muradashvili, Nino, Tyagi, Reeta, Metreveli, Naira, Tyagi, Suresh C, Lominadze, David
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2014
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Original Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4158659/
https://ncbi.nlm.nih.gov/pubmed/24865997
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/jcbfm.2014.102
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