Reduced Sensitivity to Human Serum Inactivation of Enveloped Viruses Produced by Pig Cells Transgenic for Human CD55 or Deficient for the Galactosyl-α(1-3) Galactosyl Epitope

Complement activation mediated by the major xenogeneic epitope in the pig, galactosyl-α(1-3) galactosyl sugar structure (α-Gal), and human natural antibodies could cause hyperacute rejection (HAR) in pig-to-human xenotransplantation. The same reaction on viruses bearing α-Gal may serve as a barrier...

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Bibliografiska uppgifter
Huvudupphovsmän: Magre, Saema, Takeuchi, Yasuhiro, Langford, Gillian, Richards, Andrew, Patience, Clive, Weiss, Robin
Materialtyp: Artigo
Språk:Inglês
Publicerad: American Society for Microbiology 2004
Ämnen:
Pathogenesis and Immunity
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC415822/
https://ncbi.nlm.nih.gov/pubmed/15140979
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.78.11.5812-5819.2004
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