Multivalent Antiviral XTEN–Peptide Conjugates with Long in Vivo Half-Life and Enhanced Solubility

[Image: see text] XTENs are unstructured, nonrepetitive protein polymers designed to prolong the in vivo half-life of pharmaceuticals by introducing a bulking effect similar to that of poly(ethylene glycol). While XTEN can be expressed as a recombinant fusion protein with bioactive proteins and pept...

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Detalhes bibliográficos
Main Authors: Ding, Sheng, Song, Michael, Sim, Bee-Cheng, Gu, Chen, Podust, Vladimir N., Wang, Chia-Wei, McLaughlin, Bryant, Shah, Trishul P, Lax, Rodney, Gast, Rainer, Sharan, Rahul, Vasek, Arthur, Hartman, M. Amanda, Deniston, Colin, Srinivas, Prathna, Schellenberger, Volker
Formato: Artigo
Idioma:Inglês
Publicado em: American Chemical Society 2014
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4157762/
https://ncbi.nlm.nih.gov/pubmed/24932887
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/bc500215m
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