Safety, Tolerability, and Clinical Effect of Low-Dose Buprenorphine for Treatment-Resistant Depression in Mid-Life and Older Adults

OBJECTIVE: Describe the clinical effect and safety of low-dose buprenorphine, a kappa-opioid receptor antagonist, for treatment-resistant depression (TRD) in mid-life and older adults. METHOD: Using an open-label protocol, buprenorphine was prescribed for 15 adults age 50 and older with TRD, diagnos...

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Detalhes bibliográficos
Main Authors: Karp, Jordan F., Butters, Meryl A, Begley, Amy, Miller, Mark D., Lenze, Eric J., Blumberger, Daniel, Mulsant, Benoit, Reynolds, Charles F.
Formato: Artigo
Idioma:Inglês
Publicado em: 2014
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4157317/
https://ncbi.nlm.nih.gov/pubmed/25191915
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4088/JCP.13m08725
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