Immune subdominant antigens as vaccine candidates against Mycobacterium tuberculosis()

Unlike most pathogens many of the immunodominant epitopes from Mycobacterium tuberculosis (Mtb) are under purifying selection. This startling finding suggests that Mtb may gain an evolutionary advantage by focusing the human immune response against selected proteins. Although the implications of thi...

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Hlavní autoři: Orr, Mark T., Ireton, Gregory C., Beebe, Elyse A., Huang, Po-Wei D., Reese, Valerie A., Argilla, David, Coler, Rhea N., Reed, Steven G.
Médium: Artigo
Jazyk:Inglês
Vydáno: 2014
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4157111/
https://ncbi.nlm.nih.gov/pubmed/25086172
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4049/jimmunol.1401103
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