Fungal Metabolite Gliotoxin Inhibits Assembly of the Human Respiratory Burst NADPH Oxidase

Reactive oxygen species are a critical weapon in the killing of Aspergillus fumigatus by polymorphonuclear leukocytes (PMN), as demonstrated by severe aspergillosis in chronic granulomatous disease. In the present study, A. fumigatus-produced mycotoxins (fumagillin, gliotoxin [GT], and helvolic acid...

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Bibliographische Detailangaben
Hauptverfasser: Tsunawaki, Shohko, Yoshida, Lucia S., Nishida, Satoshi, Kobayashi, Toshihiro, Shimoyama, Takashi
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Microbiology 2004
Schlagworte:
Host Response and Inflammation
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC415710/
https://ncbi.nlm.nih.gov/pubmed/15155643
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/IAI.72.6.3373-3382.2004
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