Increased levels of soluble interleukin-6 receptor and CCL3 in COPD sputum

BACKGROUND: COPD patients have increased numbers of macrophages and neutrophils in the lungs. Interleukin-6 (IL-6) trans-signaling via its soluble receptor sIL-6R, governs the influx of innate immune cells to inflammatory foci through regulation of the chemokine CCL3. We hypothesized that there woul...

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Detalhes bibliográficos
Main Authors: Ravi, Arjun K, Khurana, Shruti, Lemon, Jonathan, Plumb, Jonathan, Booth, George, Healy, Louise, Catley, Matthew, Vestbo, Jørgen, Singh, Dave
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2014
Assuntos:
Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4156958/
https://ncbi.nlm.nih.gov/pubmed/25183374
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12931-014-0103-4
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