Lenvatinib, an angiogenesis inhibitor targeting VEGFR/FGFR, shows broad antitumor activity in human tumor xenograft models associated with microvessel density and pericyte coverage

BACKGROUND: Lenvatinib is an oral inhibitor of multiple receptor tyrosine kinases (RTKs) targeting vascular endothelial growth factor receptor (VEGFR1-3), fibroblast growth factor receptor (FGFR1-4), platelet growth factor receptor α (PDGFR α), RET and KIT. Antiangiogenesis activity of lenvatinib in...

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Detalhes bibliográficos
Main Authors: Yamamoto, Yuji, Matsui, Junji, Matsushima, Tomohiro, Obaishi, Hiroshi, Miyazaki, Kazuki, Nakamura, Katsuji, Tohyama, Osamu, Semba, Taro, Yamaguchi, Atsumi, Hoshi, Sachi Suzuki, Mimura, Fusayo, Haneda, Toru, Fukuda, Yoshio, Kamata, Jun-ichi, Takahashi, Keiko, Matsukura, Masayuki, Wakabayashi, Toshiaki, Asada, Makoto, Nomoto, Ken-ichi, Watanabe, Tatsuo, Dezso, Zoltan, Yoshimatsu, Kentaro, Funahashi, Yasuhiro, Tsuruoka, Akihiko
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2014
Assuntos:
Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4156793/
https://ncbi.nlm.nih.gov/pubmed/25197551
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/2045-824X-6-18
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