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Protease-resistant SOD1 aggregates in amyotrophic lateral sclerosis demonstrated by paraffin-embedded tissue (PET) blot

OBJECTIVES: The paraffin-embedded tissue (PET) blot technique followed by limited protease digestion has been established to detect protein aggregates in prion diseases, alpha-synucleopathies, and tauopathies. We analyzed whether the scope of the method can be extended to analyze aggregates in mouse...

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Detalhes bibliográficos
Main Authors: Steinacker, Petra, Berner, Christian, Thal, Dietmar R, Attems, Johannes, Ludolph, Albert C, Otto, Markus
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2014
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4156642/
https://ncbi.nlm.nih.gov/pubmed/25159221
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s40478-014-0130-x
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