Hierarchical Molecular Events Driven by Oocyte-Specific Factors Lead to Rapid and Extensive Reprogramming

Nuclear transfer to oocytes is an efficient way to transcriptionally reprogram somatic nuclei, but its mechanisms remain unclear. Here, we identify a sequence of molecular events that leads to rapid transcriptional reprogramming of somatic nuclei after transplantation to Xenopus oocytes. RNA-seq ana...

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Главные авторы: Jullien, Jerome, Miyamoto, Kei, Pasque, Vincent, Allen, George E., Bradshaw, Charles R., Garrett, Nigel J., Halley-Stott, Richard P., Kimura, Hiroshi, Ohsumi, Keita, Gurdon, John B.
Формат: Artigo
Язык:Inglês
Опубликовано: Cell Press 2014
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Article
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC4156308/
https://ncbi.nlm.nih.gov/pubmed/25066233
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molcel.2014.06.024
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