Melanocortin 1 Receptor-Signaling Deficiency Results in an Articular Cartilage Phenotype and Accelerates Pathogenesis of Surgically Induced Murine Osteoarthritis

Proopiomelanocortin-derived peptides exert pleiotropic effects via binding to melanocortin receptors (MCR). MCR-subtypes have been detected in cartilage and bone and mediate an increasing number of effects in diathrodial joints. This study aims to determine the role of MC1-receptors (MC1) in joint p...

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Detalhes bibliográficos
Main Authors: Lorenz, Julia, Seebach, Elisabeth, Hackmayer, Gerit, Greth, Carina, Bauer, Richard J., Kleinschmidt, Kerstin, Bettenworth, Dominik, Böhm, Markus, Grifka, Joachim, Grässel, Susanne
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2014
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4156302/
https://ncbi.nlm.nih.gov/pubmed/25191747
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0105858
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