Effects of a Disrupted Blood-Brain Barrier on Cholesterol Homeostasis in the Brain

The presence of the blood-brain barrier (BBB) is critical for cholesterol metabolism in the brain, preventing uptake of lipoprotein-bound cholesterol from the circulation. The metabolic consequences of a leaking BBB for cholesterol metabolism have not been studied previously. Here we used a pericyte...

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Hlavní autoři: Saeed, Ahmed A., Genové, Guillem, Li, Tian, Lütjohann, Dieter, Olin, Maria, Mast, Natalia, Pikuleva, Irina A., Crick, Peter, Wang, Yuqin, Griffiths, William, Betsholtz, Christer, Björkhem, Ingemar
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Biochemistry and Molecular Biology 2014
Témata:
Lipids
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4156098/
https://ncbi.nlm.nih.gov/pubmed/24973215
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M114.556159
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