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Prolactin (PRL)-stimulated Ubiquitination of ZnT2 Mediates a Transient Increase in Zinc Secretion Followed by ZnT2 Degradation in Mammary Epithelial Cells

The zinc transporter ZnT2 imports zinc into secretory vesicles and regulates zinc export from the mammary epithelial cell. Mutations in ZnT2 substantially impair zinc secretion into milk. The lactogenic hormone prolactin (PRL) transcriptionally increases ZnT2 expression through the Jak2/STAT5 signal...

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Bibliografski detalji
Glavni autori: Seo, Young Ah, Lee, Sooyeon, Hennigar, Stephen R., Kelleher, Shannon L.
Format: Artigo
Jezik:Inglês
Izdano: American Society for Biochemistry and Molecular Biology 2014
Teme:
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4156067/
https://ncbi.nlm.nih.gov/pubmed/25016022
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M113.531145
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