Direct Site-Specific Radiolabeling of an Affibody Protein with 4-[(18)F]Fluorobenzaldehyde via Oxime Chemistry

PURPOSE: In this study, we introduce a methodology for preparing (18)F-labeled Affibody protein, specifically (18)F-Anti-HER2 dimeric Affibody (14 kDa), for in vivo imaging of HER2neu with positron emission tomography (PET). PROCEDURES: We have used 4-[(18)F]fluorobenzaldehyde as a synthon to prepar...

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Detalhes bibliográficos
Main Authors: Namavari, Mohammad, Padilla De Jesus, Omayra, Cheng, Zhen, De, Abhijit, Kovacs, Ernest, Levi, Jelena, Zhang, Rong, Hoerner, Joshua K., Grade, Hans, Syud, Faisal A., Gambhir, Sanjiv S.
Formato: Artigo
Idioma:Inglês
Publicado em: 2008
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4155982/
https://ncbi.nlm.nih.gov/pubmed/18481153
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s11307-008-0142-7
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