The Molecular Mechanism of Shiga Toxin Stx2e Neutralization by a Single-domain Antibody Targeting the Cell Receptor-binding Domain

Shiga toxin Stx2e is the major known agent that causes edema disease in newly weaned pigs. This severe disease is characterized by neurological disorders, hemorrhagic lesions, and frequent fatal outcomes. Stx2e consists of an enzymatically active A subunit and five B subunits that bind to a specific...

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Hlavní autoři: Lo, Alvin W. H., Moonens, Kristof, De Kerpel, Maia, Brys, Lea, Pardon, Els, Remaut, Han, De Greve, Henri
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Biochemistry and Molecular Biology 2014
Témata:
Microbiology
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4155698/
https://ncbi.nlm.nih.gov/pubmed/25053417
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M114.566257
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