The Intestinal Epithelial Cell Differentiation Marker Intestinal Alkaline Phosphatase (ALPi) Is Selectively Induced by Histone Deacetylase Inhibitors (HDACi) in Colon Cancer Cells in a Kruppel-like Factor 5 (KLF5)-dependent Manner

The histone deacetylase inhibitor (HDACi) sodium butyrate promotes differentiation of colon cancer cells as evidenced by induced expression and enzyme activity of the differentiation marker intestinal alkaline phosphatase (ALPi). Screening of a panel of 33 colon cancer cell lines identified cell lin...

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Bibliographische Detailangaben
Hauptverfasser: Shin, Joongho, Carr, Azadeh, Corner, Georgia A., Tögel, Lars, Dávaos-Salas, Mercedes, Tran, Hoanh, Chueh, Anderly C., Al-Obaidi, Sheren, Chionh, Fiona, Ahmed, Naseem, Buchanan, Daniel D., Young, Joanne P., Malo, Madhu S., Hodin, Richard A., Arango, Diego, Sieber, Oliver M., Augenlicht, Leonard H., Dhillon, Amardeep S., Weber, Thomas K., Mariadason, John M.
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Biochemistry and Molecular Biology 2014
Schlagworte:
Gene Regulation
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4155692/
https://ncbi.nlm.nih.gov/pubmed/25037223
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M114.557546
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