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Statistical monitoring of weak spots for improvement of normalization and ratio estimates in microarrays

BACKGROUND: Several aspects of microarray data analysis are dependent on identification of genes expressed at or near the limits of detection. For example, regression-based normalization methods rely on the premise that most genes in compared samples are expressed at similar levels and therefore req...

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Autors principals: Dozmorov, Igor, Knowlton, Nicholas, Tang, Yuhong, Centola, Michael
Format: Artigo
Idioma:Inglês
Publicat: BioMed Central 2004
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC415561/
https://ncbi.nlm.nih.gov/pubmed/15128432
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1471-2105-5-53
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