Ezetimibe suppresses cholesterol accumulation in lipid-loaded vascular smooth muscle cells in vitro via MAPK signaling

AIM: To investigate the mechanisms of anti-atherosclerotic action of ezetimibe in rat vascular smooth muscle cells (VSMCs) in vitro. METHODS: VSMCs of SD rats were cultured in the presence of Chol:MβCD (10 μg/mL) for 72 h, and intracellular lipid droplets and cholesterol levels were evaluated using...

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Bibliographic Details
Main Authors: Qin, Li, Yang, Yun-bo, Yang, Yi-xin, Zhu, Neng, Gong, Yong-zhen, Zhang, Cai-ping, Li, Shun-xiang, Liao, Duan-fang
Format: Artigo
Language:Inglês
Published: Nature Publishing Group 2014
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Original Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4155523/
https://ncbi.nlm.nih.gov/pubmed/25087996
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/aps.2014.10
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