Hyperthermia Inhibits Recombination Repair of Gemcitabine-Stalled Replication Forks

BACKGROUND: Gemcitabine is a potent nucleoside analogue against solid tumors, but development of drug resistance is a substantial problem. Removal of gemcitabine incorporated into DNA by repair mechanisms may contribute to resistance in chemo-refractory solid tumors. Human hepatocellular carcinoma (...

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Autors principals: Raoof, Mustafa, Zhu, Cihui, Cisneros, Brandon T., Liu, Heping, Corr, Stuart J., Wilson, Lon J., Curley, Steven A.
Format: Artigo
Idioma:Inglês
Publicat: Oxford University Press 2014
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4155430/
https://ncbi.nlm.nih.gov/pubmed/25128695
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/jnci/dju183
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