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The Moonwalker Mouse: New Insights into TRPC3 Function, Cerebellar Development, and Ataxia
The Moonwalker (Mwk) mouse is a recent model of dominantly inherited cerebellar ataxia. The motor phenotype of the Mwk mouse is due to a gain-of-function mutation in the gene encoding the cation-permeable transient receptor potential channel (TRPC3). This mutation converts a threonine into an alanin...
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Springer US
2014
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| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4155175/ https://ncbi.nlm.nih.gov/pubmed/24797279 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s12311-014-0564-5 |
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