A Naturally Occurring Lgr4 Splice Variant Encodes a Soluble Antagonist Useful for Demonstrating the Gonadal Roles of Lgr4 in Mammals

Leucine-rich repeat containing G protein-coupled receptor 4 (LGR4) promotes the Wnt signaling through interaction with R-spondins or norrin. Using PCR amplification from rat ovarian cDNAs, we identified a naturally occurring Lgr4 splice variant encoding only the ectodomain of Lgr4, which was named L...

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Bibliographic Details
Main Authors: Hsu, Pei-Jen, Wu, Fang-Ju, Kudo, Masataka, Hsiao, Chih-Lun, Hsueh, Aaron J. W., Luo, Ching-Wei
Format: Artigo
Language:Inglês
Published: Public Library of Science 2014
Subjects:
Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4154783/
https://ncbi.nlm.nih.gov/pubmed/25188337
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0106804
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