Systematic Production of Inactivating and Non-Inactivating Suppressor Mutations at the relA Locus That Compensate the Detrimental Effects of Complete spoT Loss and Affect Glycogen Content in Escherichia coli

In Escherichia coli, ppGpp is a major determinant of growth and glycogen accumulation. Levels of this signaling nucleotide are controlled by the balanced activities of the ppGpp RelA synthetase and the dual-function hydrolase/synthetase SpoT. Here we report the construction of spoT null (ΔspoT) muta...

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Bibliographic Details
Main Authors: Montero, Manuel, Rahimpour, Mehdi, Viale, Alejandro M., Almagro, Goizeder, Eydallin, Gustavo, Sevilla, Ángel, Cánovas, Manuel, Bernal, Cristina, Lozano, Ana Belén, Muñoz, Francisco José, Baroja-Fernández, Edurne, Bahaji, Abdellatif, Mori, Hirotada, Codoñer, Francisco M., Pozueta-Romero, Javier
Format: Artigo
Language:Inglês
Published: Public Library of Science 2014
Subjects:
Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4154780/
https://ncbi.nlm.nih.gov/pubmed/25188023
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0106938
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