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Striatal Astrocytes Act as a Reservoir for L-DOPA
L-DOPA is therapeutically efficacious in patients with Parkinson’s disease (PD), although dopamine (DA) neurons are severely degenerated. Since cortical astrocytes express neutral amino acid transporter (LAT) and DA transporter (DAT), the uptake and metabolism of L-DOPA and DA in striatal astrocytes...
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| Hauptverfasser: | , , , , |
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| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
Public Library of Science
2014
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4154692/ https://ncbi.nlm.nih.gov/pubmed/25188235 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0106362 |
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