Construction of a 2.8-megabase yeast artificial chromosome contig and cloning of the human methylthioadenosine phosphorylase gene from the tumor suppressor region on 9p21.

Many human malignant cells lack methylthioadenosine phosphorylase (MTAP) enzyme activity. The gene (MTAP) encoding this enzyme was previously mapped to the short arm of chromosome 9, band p21-22, a region that is frequently deleted in multiple tumor types. To clone candidate tumor suppressor genes f...

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Detalhes bibliográficos

Publicado no:	Proc Natl Acad Sci U S A
Principais autores:	Olopade, O I, Pomykala, H M, Hagos, F, Sveen, L W, Espinosa, R, Dreyling, M H, Gursky, S, Stadler, W M, Le Beau, M M, Bohlander, S K
Formato:	Artigo
Idioma:	Inglês
Publicado em:	National Academy of Sciences 1995
Assuntos:	Research Article
Acesso em linha:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC41543/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/7604019/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.92.14.6489
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