Construction of a 2.8-megabase yeast artificial chromosome contig and cloning of the human methylthioadenosine phosphorylase gene from the tumor suppressor region on 9p21.

Many human malignant cells lack methylthioadenosine phosphorylase (MTAP) enzyme activity. The gene (MTAP) encoding this enzyme was previously mapped to the short arm of chromosome 9, band p21-22, a region that is frequently deleted in multiple tumor types. To clone candidate tumor suppressor genes f...

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Vydáno v:	Proc Natl Acad Sci U S A
Hlavní autoři:	Olopade, O I, Pomykala, H M, Hagos, F, Sveen, L W, Espinosa, R, Dreyling, M H, Gursky, S, Stadler, W M, Le Beau, M M, Bohlander, S K
Médium:	Artigo
Jazyk:	Inglês
Vydáno:	National Academy of Sciences 1995
Témata:	Research Article
On-line přístup:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC41543/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/7604019/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.92.14.6489
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Construction of a 2.8-megabase yeast artificial chromosome contig and cloning of the human methylthioadenosine phosphorylase gene from the tumor suppressor region on 9p21.

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