Construction of a 2.8-megabase yeast artificial chromosome contig and cloning of the human methylthioadenosine phosphorylase gene from the tumor suppressor region on 9p21.

Many human malignant cells lack methylthioadenosine phosphorylase (MTAP) enzyme activity. The gene (MTAP) encoding this enzyme was previously mapped to the short arm of chromosome 9, band p21-22, a region that is frequently deleted in multiple tumor types. To clone candidate tumor suppressor genes f...

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Detalhes bibliográficos
Main Authors: Olopade, O I, Pomykala, H M, Hagos, F, Sveen, L W, Espinosa, R, Dreyling, M H, Gursky, S, Stadler, W M, Le Beau, M M, Bohlander, S K
Formato: Artigo
Idioma:Inglês
Publicado em: 1995
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC41543/
https://ncbi.nlm.nih.gov/pubmed/7604019
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