Modulation of Poly(ADP-Ribose) Polymerase-1 (PARP-1)-Mediated Oxidative Cell Injury by Ring Finger Protein 146 (RNF146) in Cardiac Myocytes

Poly(ADP-ribose) polymerase-1 (PARP-1) activation is a hallmark of oxidative stress–induced cellular injury that can lead to energetic failure and necrotic cell death via depleting the cellular nicotinamide adenine dinucleotide (NAD(+)) and ATP pools. Pharmacological PARP-1 inhibition or genetic PAR...

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Main Authors: Gerö, Domokos, Szoleczky, Petra, Chatzianastasiou, Athanasia, Papapetropoulos, Andreas, Szabo, Csaba
Formato: Artigo
Idioma:Inglês
Publicado em: ScholarOne 2014
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4153837/
https://ncbi.nlm.nih.gov/pubmed/24842055
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2119/molmed.2014.00102
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