Productive HIV-1 Infection of Human Cervical Tissue Ex Vivo is Associated with the Secretory Phase of the Menstrual Cycle

Cervical tissue explants (CTE) from 22 HIV-1 seronegative women were exposed to R5 HIV-1 ex vivo. Eight CTE were productively infected in terms of HIV-1 p24(Gag) release in culture supernatants whereas 14 were not. Nonetheless, both accumulation of HIV-1(gag) DNA and of p24(Gag)(+) CD4(+) T cells an...

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Main Authors: Saba, Elisa, Origoni, Massimo, Taccagni, Gianluca, Ferrari, Davide, Doglioni, Claudio, Nava, Alice, Lisco, Andrea, Grivel, Jean-Charles, Margolis, Leonid, Poli, Guido
Formato: Artigo
Idioma:Inglês
Publicado em: 2013
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4153411/
https://ncbi.nlm.nih.gov/pubmed/23385427
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/mi.2013.2
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