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Site-2 protease responds to oxidative stress and regulates oxidative injury in mammalian cells

Site-2 protease (S2P) is a membrane-embedded protease that site-specifically cleaves intramembrane transcription factors, a necessary step for their maturation. S2P is well known to regulate cholesterol biosynthesis and endoplasmic reticulum stress in mammalian cells. In this study, we hypothesized...

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Detalhes bibliográficos
Main Authors: Gu, Yong, Lee, Waisin, Shen, Jiangang
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2014
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4152756/
https://ncbi.nlm.nih.gov/pubmed/25183265
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep06268
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