The catalytic region and PEST domain of PTPN18 distinctly regulate the HER2 phosphorylation and ubiquitination barcodes

The tyrosine phosphorylation barcode encoded in C-terminus of HER2 and its ubiquitination regulate diverse HER2 functions. PTPN18 was reported as a HER2 phosphatase; however, the exact mechanism by which it defines HER2 signaling is not fully understood. Here, we demonstrate that PTPN18 regulates HE...

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Bibliografski detalji
Glavni autori: Wang, Hong-Mei, Xu, Yun-Fei, Ning, Shang-Lei, Yang, Du-Xiao, Li, Yi, Du, Yu-Jie, Yang, Fan, Zhang, Ya, Liang, Nan, Yao, Wei, Zhang, Ling-Li, Gu, Li-Chuan, Gao, Cheng-Jiang, Pang, Qi, Chen, Yu-Xin, Xiao, Kun-Hong, Ma, Rong, Yu, Xiao, Sun, Jin-Peng
Format: Artigo
Jezik:Inglês
Izdano: Nature Publishing Group 2014
Teme:
Original Article
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4152746/
https://ncbi.nlm.nih.gov/pubmed/25081058
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/cr.2014.99
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