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Differential Effects of Caveolin-1 and -2 Knockdown on Aqueous Outflow and Altered Extracellular Matrix Turnover in Caveolin-Silenced Trabecular Meshwork Cells

PURPOSE. A single nucleotide polymorphism (SNP) identified between caveolin-1 (CAV1) and caveolin-2 (CAV2) on chromosome 7 is associated with glaucoma. One function of CAVs is endocytosis and recycling of extracellular matrix (ECM) components. Here, we generated CAV-silencing lentivirus to evaluate...

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Main Authors: Aga, Mini, Bradley, John M., Wanchu, Rohan, Yang, Yong-feng, Acott, Ted S., Keller, Kate E.
Formato: Artigo
Idioma:Inglês
Publicado: The Association for Research in Vision and Ophthalmology 2014
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Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC4152152/
https://ncbi.nlm.nih.gov/pubmed/25103269
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1167/iovs.14-14519
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