A novel system for predicting the toxicity of irinotecan based on statistical pattern recognition with UGT1A genotypes

To predict precisely severe toxicity of irinotecan, we evaluated the association of UGT1A variants, haplotypes and the combination of UGT1A genotypes to severe toxicity of irinotecan. UGT1A1*6 (211G>A), UGT1A1*28 (TA(6)>TA(7)), UGT1A1*60 (−3279T>G), UGT1A7 (387T>G), UGT1A7 (622T>C), a...

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Main Authors: TSUNEDOMI, RYOUICHI, HAZAMA, SHOICHI, FUJITA, YUSUKE, OKAYAMA, NAOKO, KANEKIYO, SHINSUKE, INOUE, YUKA, YOSHINO, SHIGEFUMI, YAMASAKI, TAKAHIRO, SUEHIRO, YUTA KA, OBA, KOJI, MISHIMA, HIDEYUKI, SAKAMOTO, JUNICHI, HAMAMOTO, YOSHIHIKO, OKA, MASAKI
Formato: Artigo
Idioma:Inglês
Publicado em: D.A. Spandidos 2014
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Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4151810/
https://ncbi.nlm.nih.gov/pubmed/25175642
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3892/ijo.2014.2556
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