Microbial-induced meprin β cleavage in MUC2 mucin and a functional CFTR channel are required to release anchored small intestinal mucus

The mucus that covers and protects the epithelium of the intestine is built around its major structural component, the gel-forming MUC2 mucin. The gel-forming mucins have traditionally been assumed to be secreted as nonattached. The colon has a two-layered mucus system where the inner mucus is attac...

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Détails bibliographiques
Auteurs principaux: Schütte, André, Ermund, Anna, Becker-Pauly, Christoph, Johansson, Malin E. V., Rodriguez-Pineiro, Ana M., Bäckhed, Fredrik, Müller, Stefan, Lottaz, Daniel, Bond, Judith S., Hansson, Gunnar C.
Format: Artigo
Langue:Inglês
Publié: National Academy of Sciences 2014
Sujets:
Biological Sciences
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC4151749/
https://ncbi.nlm.nih.gov/pubmed/25114233
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1407597111
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