Inhibitor of MYC identified in a Kröhnke pyridine library

In a fluorescence polarization screen for the MYC–MAX interaction, we have identified a novel small-molecule inhibitor of MYC, KJ-Pyr-9, from a Kröhnke pyridine library. The K(d) of KJ-Pyr-9 for MYC in vitro is 6.5 ± 1.0 nM, as determined by backscattering interferometry; KJ-Pyr-9 also interferes wi...

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Main Authors: Hart, Jonathan R., Garner, Amanda L., Yu, Jing, Ito, Yoshihiro, Sun, Minghao, Ueno, Lynn, Rhee, Jin-Kyu, Baksh, Michael M., Stefan, Eduard, Hartl, Markus, Bister, Klaus, Vogt, Peter K., Janda, Kim D.
Format: Artigo
Jezik:Inglês
Izdano: National Academy of Sciences 2014
Teme:
Biological Sciences
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC4151726/
https://ncbi.nlm.nih.gov/pubmed/25114221
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1319488111
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