Immunoglobulin variable region hypermutation in hybrids derived from a pre-B- and a myeloma cell line.
Somatic mutation of the variable (V) regions of immunoglobulin genes occurs in vivo at rates that have been estimated to be between 10(-3) and 10(-4) per bp per generation. To study this process in vitro, the 18.81 pre-B-cell line and hybrids derived by fusing 18.81 to the NSO myeloma fusion partner...
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| Publicat a: | Proc Natl Acad Sci U S A |
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| Autors principals: | , , , , |
| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
National Academy of Sciences
1995
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC41506/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/7603987/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.92.14.6304 |
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