Flavopiridol Can Be Safely Administered Using a Pharmacologically Derived Schedule and Demonstrates Activity in Relapsed and Refractory Non-Hodgkin’s Lymphoma

Flavopiridol is a broad cyclin-dependent kinase inhibitor (CDKI) that induces apoptosis of malignant lymphocytes in vitro and in murine lymphoma models. We conducted a phase I dose-escalation study to determine the maximum tolerated dose (MTD) for single-agent flavopiridol administered on a pharmaco...

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Hoofdauteurs: Jones, Jeffrey A., Rupert, Amy S., Poi, Ming, Phelps, Mitch A., Andritsos, Leslie, Baiocchi, Robert, Benson, Don M., Blum, Kristie A., Christian, Beth, Flynn, Joseph, Penza, Sam, Porcu, Pierluigi, Grever, Michael R., Byrd, John C.
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: 2013
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Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4150545/
https://ncbi.nlm.nih.gov/pubmed/23959599
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/ajh.23568
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