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Axonally synthesized ATF4 transmits a neurodegenerative signal across brain regions
In Alzheimer’s disease (AD) brain exposure of axons to Aβ causes pathogenic changes that spread retrogradely by unknown mechanisms affecting the entire neuron. We found that locally applied Aβ(1–42) initiates axonal synthesis of a defined set of proteins including the transcription factor ATF4. Inhi...
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| Autori principali: | , , , , , , |
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| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
2014
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4149755/ https://ncbi.nlm.nih.gov/pubmed/25171414 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cell.2014.07.001 |
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