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133 Structural basis for ebolavirus matrix assembly and budding; protein plasticity allows multiple functions

Proteins, particularly viral proteins, can be multifunctional, but the mechanism(s) behind this trait are not fully understood. Here, we illustrate through multiple crystal structures, biochemistry and cellular microscopy that the Ebola virus VP40 protein rearranges into different structures, each w...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: Bornholdt, Zachary, Noda, Takeshi, Abelson, Dafna, Halfmann, Peter, Wood, Malcolm, Kawaoa, Yoshihiro, Saphire, Erica Ollmann
Format: Artigo
Sprache:Inglês
Veröffentlicht: JAIDS Journal of Acquired Immune Deficiency Syndromes 2014
Schlagworte:
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4149652/
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1097/01.qai.0000446713.32982.25
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