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Control of Asymmetric Hopfield Networks and Application to Cancer Attractors

The asymmetric Hopfield model is used to simulate signaling dynamics in gene regulatory networks. The model allows for a direct mapping of a gene expression pattern into attractor states. We analyze different control strategies aimed at disrupting attractor patterns using selective local fields repr...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: Szedlak, Anthony, Paternostro, Giovanni, Piermarocchi, Carlo
Format: Artigo
Sprache:Inglês
Veröffentlicht: Public Library of Science 2014
Schlagworte:
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4149479/
https://ncbi.nlm.nih.gov/pubmed/25170874
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0105842
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