Vasa vasorum anti-angiogenesis through H(2)O(2), HIF-1α, NF-κB, and iNOS inhibition by mangosteen pericarp ethanolic extract (Garcinia mangostana Linn) in hypercholesterol-diet-given Rattus norvegicus Wistar strain

BACKGROUND: Oxidative stress in atherosclerosis produces H(2)O(2) and triggers the activation of nuclear factor kappa beta (NF-κB) and increase of inducible nitric oxide synthase (iNOS). The formation of vasa vasorum occurs in atherosclerosis. Vasa vasorum angiogenesis is mediated by VEGFR-1 and upr...

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Главные авторы: Wihastuti, Titin Andri, Sargowo, Djanggan, Tjokroprawiro, Askandar, Permatasari, Nur, Widodo, Mohammad Aris, Soeharto, Setyowati
Формат: Artigo
Язык:Inglês
Опубликовано: Dove Medical Press 2014
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Original Research
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC4149390/
https://ncbi.nlm.nih.gov/pubmed/25187725
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2147/VHRM.S61736
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