Poly-A binding protein-1 localization to a subset of TAR DNA-binding protein of 43 kDa inclusions in amyotrophic lateral sclerosis occurs more frequently in patients harboring an expansion in C9orf72

Amyotrophic lateral sclerosis (ALS) is an adult-onset motor neuron disease in which the loss of spinal cord motor neurons leads to paralysis and death within a few years of clinical disease onset. In almost all cases of ALS, TAR DNA binding protein of 43 kDa (TDP-43) forms cytoplasmic neuronal inclu...

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Huvudupphovsmän: McGurk, Leeanne, Lee, Virginia, M., Trojanowksi, John Q., Van Deerlin, Vivianna M., Lee, Edward B., Bonini, Nancy M.
Materialtyp: Artigo
Språk:Inglês
Publicerad: 2014
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Article
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC4149258/
https://ncbi.nlm.nih.gov/pubmed/25111021
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1097/NEN.0000000000000102
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