Neuroprotective effects of progesterone in traumatic brain injury: blunted in vivo neutrophil activation at the blood-brain barrier

BACKGROUND: Progesterone (PRO) may confer a survival advantage in traumatic brain injury (TBI) by reducing cerebral edema. We hypothesized that PRO reduces edema by blocking polymorphonuclear (PMN) interactions with endothelium (EC) in the blood-brain barrier (BBB). METHODS: CD1 mice received repeat...

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Main Authors: Pascual, Jose L., Murcy, Mohammad A., Li, Shenghui, Gong, Wanfeng, Eisenstadt, Rachel, Kumasaka, Kenichiro, Sims, Carrie, Smith, Douglas H., Browne, Kevin, Allen, Steve, Baren, Jill
Format: Artigo
Language:Inglês
Published: 2013
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4149185/
https://ncbi.nlm.nih.gov/pubmed/24112683
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.amjsurg.2013.07.016
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