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Polymorphisms in Catechol-O-methyltransferase Modify Treatment Effects of Aspirin on Risk of Cardiovascular Disease

OBJECTIVE: Catechol-O-methyltransferase (COMT), a key enzyme in catecholamine metabolism, is implicated in cardiovascular, sympathetic, and endocrine pathways. This study aimed to confirm preliminary association of COMT genetic variation with incident cardiovascular disease (CVD). It further aimed t...

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Detalhes bibliográficos
Main Authors: Hall, Kathryn T., Nelson, Christopher P., Davis, Roger B., Buring, Julie E., Kirsch, Irving, Mittleman, Murray A., Loscalzo, Joseph, Samani, Nilesh J., Ridker, Paul M, Kaptchuk, Ted J., Chasman, Daniel I.
Formato: Artigo
Idioma:Inglês
Publicado em: 2014
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4148908/
https://ncbi.nlm.nih.gov/pubmed/25035343
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/ATVBAHA.114.303845
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