A Cysteine Protease Inhibitor of Plasmodium berghei Is Essential for Exo-erythrocytic Development

Plasmodium parasites express a potent inhibitor of cysteine proteases (ICP) throughout their life cycle. To analyze the role of ICP in different life cycle stages, we generated a stage-specific knockout of the Plasmodium berghei ICP (PbICP). Excision of the pbicb gene occurred in infective sporozoit...

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Autori principali: Lehmann, Christine, Heitmann, Anna, Mishra, Satish, Burda, Paul-Christian, Singer, Mirko, Prado, Monica, Niklaus, Livia, Lacroix, Céline, Ménard, Robert, Frischknecht, Friedrich, Stanway, Rebecca, Sinnis, Photini, Heussler, Volker
Natura: Artigo
Lingua:Inglês
Pubblicazione: Public Library of Science 2014
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Research Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4148452/
https://ncbi.nlm.nih.gov/pubmed/25166051
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.ppat.1004336
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