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Effects of metformin and other biguanides on oxidative phosphorylation in mitochondria
The biguanide metformin is widely prescribed for Type II diabetes and has anti-neoplastic activity in laboratory models. Despite evidence that inhibition of mitochondrial respiratory complex I by metformin is the primary cause of its cell-lineage-specific actions and therapeutic effects, the molecul...
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| Main Authors: | , , , |
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| Format: | Artigo |
| Language: | Inglês |
| Published: |
Portland Press Ltd.
2014
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| Subjects: | |
| Online Access: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4148174/ https://ncbi.nlm.nih.gov/pubmed/25017630 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1042/BJ20140620 |
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