The MAPK pathway as an apoptosis enhancer in melanoma

Inhibition of RAF/MEK/ERK signaling is beneficial for many patients with BRAF(V600E)–mutated melanoma. However, primary and secondary resistances restrict long-lasting therapy success. Combination therapies are therefore urgently needed. Here, we evaluate the cellular effect of combining a MEK inhib...

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Autori principali: Haydn, Johannes M., Hufnagel, Anita, Grimm, Johannes, Maurus, Katja, Schartl, Manfred, Meierjohann, Svenja
Natura: Artigo
Lingua:Inglês
Pubblicazione: Impact Journals LLC 2014
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Research Paper
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4148120/
https://ncbi.nlm.nih.gov/pubmed/24970815
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