Caricamento...

Combining AKT inhibition with chloroquine and gefitinib prevents compensatory autophagy and induces cell death in EGFR mutated NSCLC cells

Although non-small cell lung cancer (NSCLC) patients with EGFR mutation positive (EGFR M+) tumors initially respond well to EGFR tyrosine kinase inhibitor (TKI) monotherapy, the responses are usually incomplete. In this study we show that AKT inhibition, most importantly AKT2 inhibition, synergises...

Descrizione completa

Salvato in:
Dettagli Bibliografici
Autori principali: Bokobza, Sivan M., Jiang, Yanyan, Weber, Anika M., Devery, Aoife M., Ryan, Anderson J.
Natura: Artigo
Lingua:Inglês
Pubblicazione: Impact Journals LLC 2014
Soggetti:
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4148097/
https://ncbi.nlm.nih.gov/pubmed/24946858
Tags: Aggiungi Tag
Nessun Tag, puoi essere il primo ad aggiungerne! !