Intrinsic bevacizumab resistance is associated with prolonged activation of autocrine VEGF signaling and hypoxia tolerance in colorectal cancer cells and can be overcome by nintedanib, a small molecule angiokinase inhibitor

Lignende værker

• Replication and homologous recombination repair regulate DNA double-strand break formation by the antitumor alkylator ecteinascidin 743
  af: Soares, Daniele Grazziotin, et al.
  Udgivet: (2007)
• Nintedanib, a triple angiokinase inhibitor, enhances cytotoxic therapy response in pancreatic cancer
  af: Awasthi, Niranjan, et al.
  Udgivet: (2014)
• Prolonged response of relapsed high grade serous ovarian carcinoma to the oral angiokinase inhibitor nintedanib in a patient with a germline BRCA1 mutation
  af: Wong, Han Hsi, et al.
  Udgivet: (2012)
• The Effect of Bevacizumab on Human Malignant Melanoma Cells with Functional VEGF/VEGFR2 Autocrine and Intracrine Signaling Loops
  af: Una Adamcic, et al.
  Udgivet: (2012-07-01)
• The Effect of Bevacizumab on Human Malignant Melanoma Cells with Functional VEGF/VEGFR2 Autocrine and Intracrine Signaling Loops
  af: Adamcic, Una, et al.
  Udgivet: (2012)