Chronic mitochondrial energy impairment produces selective striatal degeneration and abnormal choreiform movements in primates.

Although the gene defect responsible for Huntington disease (HD) has recently been identified, the pathogenesis of the disease remains obscure. One potential mechanism is that the gene defect may lead to an impairment of energy metabolism followed by slow excitotoxic neuronal injury. In the present...

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Main Authors: Brouillet, E, Hantraye, P, Ferrante, R J, Dolan, R, Leroy-Willig, A, Kowall, N W, Beal, M F
Format: Artigo
Sprog:Inglês
Udgivet: 1995
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC41480/
https://ncbi.nlm.nih.gov/pubmed/7624378
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