Chronic mitochondrial energy impairment produces selective striatal degeneration and abnormal choreiform movements in primates.

Although the gene defect responsible for Huntington disease (HD) has recently been identified, the pathogenesis of the disease remains obscure. One potential mechanism is that the gene defect may lead to an impairment of energy metabolism followed by slow excitotoxic neuronal injury. In the present...

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הוצא לאור ב:	Proc Natl Acad Sci U S A
Principais autores:	Brouillet, E, Hantraye, P, Ferrante, R J, Dolan, R, Leroy-Willig, A, Kowall, N W, Beal, M F
פורמט:	Artigo
שפה:	Inglês
יצא לאור:	National Academy of Sciences 1995
נושאים:	Research Article
גישה מקוונת:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC41480/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/7624378/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.92.15.7105
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