Diurnal Variation in P-glycoprotein-Mediated Transport and Cerebrospinal Fluid Turnover in the Brain

Nearly all bodily processes exhibit circadian rhythmicity. As a consequence, the pharmacokinetic and pharmacodynamic properties of a drug may also vary with time of day. The objective of this study was to investigate diurnal variation in processes that regulate drug concentrations in the brain, focu...

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Bibliographic Details
Main Authors: Kervezee, Laura, Hartman, Robin, van den Berg, Dirk-Jan, Shimizu, Shinji, Emoto-Yamamoto, Yumi, Meijer, Johanna H., de Lange, Elizabeth C. M.
Format: Artigo
Language:Inglês
Published: Springer US 2014
Subjects:
Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4147055/
https://ncbi.nlm.nih.gov/pubmed/24917180
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1208/s12248-014-9625-4
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