Spontaneous Genomic Alterations in a Chimeric Model of Colorectal Cancer Enable Metastasis and Guide Effective Combinatorial Therapy

Colon cancer is the second most common cause of cancer mortality in the Western world with metastasis commonly present at the time of diagnosis. Screening for propagation and metastatic behavior in a novel chimeric-mouse colon cancer model, driven by mutant p53 and β-Catenin, led to the identificati...

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Detalhes bibliográficos
Main Authors: Zhou, Yinghui, Rideout, William M., Bressel, Angela, Yalavarthi, Sireesha, Zi, Tong, Potz, Darren, Farlow, Samuel, Brodeur, Joelle, Monti, Anthony, Reddipalli, Shailaja, Xiao, Qiurong, Bottega, Steve, Feng, Bin, Chiu, M. Isabel, Bosenberg, Marcus, Heyer, Joerg
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2014
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4146580/
https://ncbi.nlm.nih.gov/pubmed/25162504
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0105886
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